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GLP-1 receptor agonists like semaglutide, liraglutide, dulaglutide and tirzepatide reduce not only fat but also lean muscle mass

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Early research shows retatrutide results in significant weight loss in people with overweight and obesity

Originally developed for diabetes management, these drugs, popularized under brand names such as Ozempic, Wegovy, Mounjaro, and Zepbound, are redefining how we think about obesity, metabolic health, and even chronic disease prevention

It is also expressed at lower levels in the gut, kidneys, liver, heart, muscle and the PNS (6)